A simple reflex arc can coordinate an appropriate response to a stimulus such as heat with just two.

A simple reflex arc can coordinate an appropriate response to a stimulus such as heat with just two or three neurons. If the incoming information says “too hot,” then the instruction “move hand” is sent out. If no “too hot” message is sent, then a “move hand” instruction does not get sent. Using four neurons, including one interneuron, design a nervous system that could decide to send the message “move” or “stay still” in response to two different stimuli that do not necessarily occur at the same time.

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